Pharmacogenomics: tailoring the drug approval process for designer drugs.
نویسنده
چکیده
منابع مشابه
Pharmacogenomics approach in psychiatry disorders
Psychiatric disorders are important health issues in the world, and their management is facing some serious challenges. Drugs that are widely used in the treatment of psychiatric disorders, including antidepressants, antipsychotics, and mood stabilizers, are often associated with many side effects and are adequately effective only in a small proportion of patients. Many factors, including genet...
متن کاملPharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapy
The new era of personalized medicine, which integrates the uniqueness of an individual with respect to the pharmacokinetics and pharmacodynamics of a drug, holds promise as a means to provide greater safety and efficacy in drug design and development. Personalized medicine is particularly important in oncology, whereby most clinically used anticancer drugs have a narrow therapeutic window and e...
متن کاملOrphan drug incentives in the pharmacogenomic context: policy responses in the US and Canada
Advances in pharmacogenomic research and increasing industry interest in personalized medicine have important implications for the way that orphan drug policies are interpreted and applied. Concerns have been raised about the potential impact of pharmacogenomics and new genomic technologies on our understanding of how disease categories are delineated, and subsequently, how the concept of rare ...
متن کاملPharmacogenetics of Cytochrome P450 2D6: A Translational Medicine Perspective
With rapid scientific advances in the postgenomic era, pharmacogenomics has developed into an important area of translational medicine research. Pharmacogenetics studies the variability in drug response between different patient genotypes. By using patient genomic information, this bench-to-bedside research approach aims to develop more effective targeting of drug therapy in clinical practice. ...
متن کاملDevelopment of a Pharmacogenomics Model based on Support Vector Regression with Optimal Features Selection Approach to Determine the Initial Therapeutic Dose of Warfarin Anticoagulant Drug
Introduction: Using artificial intelligence tools in pharmacogenomics is one of the latest bioinformatics research fields. One of the most important drugs that determining its initial therapeutic dose is difficult is the anticoagulant warfarin. Warfarin is an oral anticoagulant that, due to its narrow therapeutic window and complex interrelationships of individual factors, the selection of its ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of contemporary health law and policy
دوره 24 2 شماره
صفحات -
تاریخ انتشار 2008